Research
For over two decades, Bruce and his team have been developing and utilizing computer, AI, and systems approaches, methods, models, and tools to help decision makers better understand and address complex systems in health and public health. This has included the research efforts described below and other initiatives described here.
Bruce has been the Principal Investigator for over $60 million in grants/contracts from a variety of organizations and agencies including the National Institutes of Health (NIH), the Agency for Healthcare Quality and Research (AHRQ), the National Science Foundation (NSF), the Centers for Disease Control and Prevention (CDC), UNICEF, the Global Fund, the Bill & Melinda Gates Foundation, and the U.S. Agency for International Development (USAID).
Bruce and his PHICOR team have published over 295 publications in scientific peer-reviewed journals (e.g., The Lancet, Health Affairs, The New England Journal of Medicine, American Journal of Public Health, American Journal of Preventive Medicine) with Dr. Lee being first author for over 110 and last author for over 120 of them, most of which have been original research. Much of this research has involved working directly with a range of different local, state, national, and international decision-makers.
To find or sort these different scientific publications by topic, use the filtering option below and to the left.
Augmenting transport versus increasing cold storage to improve vaccine supply chains
Augmenting transport versus increasing cold storage to improve vaccine supply chains
The Regional Healthcare Ecosystem Analyst (RHEA): A simulation modeling tool to assist infectious disease control in a health system
The Regional Healthcare Ecosystem Analyst (RHEA): A simulation modeling tool to assist infectious disease control in a health system
A computational simulation model: The global economic burden of Chagas' disease
A computational simulation model: The global economic burden of Chagas' disease
Modeling of cost effectiveness of pneumococcal conjugate vaccination strategies in U.S. older adults
Modeling of cost effectiveness of pneumococcal conjugate vaccination strategies in U.S. older adults
Cost-effectiveness of procalcitonin-guided antibiotic use in community acquired pneumonia
Cost-effectiveness of procalcitonin-guided antibiotic use in community acquired pneumonia
The importance of nursing homes in the spread of methicillin-resistant Staphylococcus aureus (MRSA) among hospitals
The importance of nursing homes in the spread of methicillin-resistant Staphylococcus aureus (MRSA) among hospitals
The potential economic value of a human norovirus vaccine for the United States
The potential economic value of a human norovirus vaccine for the United States
School closure as an influenza mitigation strategy: How variations in legal authority and plan criteria can alter the impact
School closure as an influenza mitigation strategy: How variations in legal authority and plan criteria can alter the impact
Nursing home characteristics associated with methicillin-resistant Staphylococcus aureus (MRSA) burden and transmission
Nursing home characteristics associated with methicillin-resistant Staphylococcus aureus (MRSA) burden and transmission
The economic value of a quadrivalent versus trivalent influenza vaccine
The economic value of a quadrivalent versus trivalent influenza vaccine
Simulation shows hospitals that cooperate on infection control obtain better results than hospitals acting alone
Simulation shows hospitals that cooperate on infection control obtain better results than hospitals acting alone
Total economic cost and burden of Dengue in Nicaragua: 1996-2010
Total economic cost and burden of Dengue in Nicaragua: 1996-2010
The comparative value of various employer-sponsored influenza vaccination clinics
The comparative value of various employer-sponsored influenza vaccination clinics
The impact of making vaccines thermostable in Niger’s vaccine supply chain
The impact of making vaccines thermostable in Niger’s vaccine supply chain
Modeling the economic value of a Chagas’ disease therapeutic vaccine
Modeling the economic value of a Chagas’ disease therapeutic vaccine
The potential economic value of Clostridium difficile surveillance
The potential economic value of Clostridium difficile surveillance
Cost savings of radial artery access for coronary angiography and intervention
Cost savings of radial artery access for coronary angiography and intervention
How influenza vaccination policy may affect vaccine logistics
How influenza vaccination policy may affect vaccine logistics
The potential economic value of a Staphylococcus aureus vaccine among hemodialysis patients
The potential economic value of a Staphylococcus aureus vaccine among hemodialysis patients
The economic value of a visceral leishmaniasis vaccine in Bihar State, India
The economic value of a visceral leishmaniasis vaccine in Bihar State, India
Impact of introducing the pneumococcal and rotavirus vaccines into the routine immunization program in Niger
Impact of introducing the pneumococcal and rotavirus vaccines into the routine immunization program in Niger
Long-term care facilities: Important participants of the acute care facility social network?
Long-term care facilities: Important participants of the acute care facility social network?
Routine pre-cesarean Staphylococcus aureus screening and decolonization: A cost-effectiveness analysis
Routine pre-cesarean Staphylococcus aureus screening and decolonization: A cost-effectiveness analysis
The potential economic value of a "universal" (multi-year) influenza vaccine
The potential economic value of a "universal" (multi-year) influenza vaccine
Social network analysis of patient sharing among hospitals in Orange County, California
Social network analysis of patient sharing among hospitals in Orange County, California
Maintaining vaccine delivery following the introduction of the rotavirus and pneumococcal vaccines in Thailand
Maintaining vaccine delivery following the introduction of the rotavirus and pneumococcal vaccines in Thailand
Economic value of norovirus outbreak control measures in healthcare settings
Economic value of norovirus outbreak control measures in healthcare settings
The optimal number of routine vaccines to order at health clinics in low or middle income
The optimal number of routine vaccines to order at health clinics in low or middle income
Impact of changing the measles vaccine vial size on Niger's vaccine supply chain
Impact of changing the measles vaccine vial size on Niger's vaccine supply chain
Cost effectiveness of adjuvanted vs. non-adjuvanted influenza vaccine in adult hemodialysis patients
Cost effectiveness of adjuvanted vs. non-adjuvanted influenza vaccine in adult hemodialysis patients
The potential economic value of a hookworm vaccine
The potential economic value of a hookworm vaccine
An outbreak of 2009 pandemic influenza A (H1N1) virus infection in an elementary school in Pennsylvania
An outbreak of 2009 pandemic influenza A (H1N1) virus infection in an elementary school in Pennsylvania
Economic model for emergency use authorization of intravenous peramivir
Economic model for emergency use authorization of intravenous peramivir
The impact of mass gatherings and holiday traveling on the course of an influenza pandemic: A computational model
The impact of mass gatherings and holiday traveling on the course of an influenza pandemic: A computational model
The potential economic value of a Trypanosoma cruzi (Chagas disease) vaccine in Latin America
The potential economic value of a Trypanosoma cruzi (Chagas disease) vaccine in Latin America
Forecasting the economic value of an enterovirus 71 (EV71) vaccine
Forecasting the economic value of an enterovirus 71 (EV71) vaccine
Cost effectiveness of dual influenza and pneumococcal vaccination in 50-year-olds
Cost effectiveness of dual influenza and pneumococcal vaccination in 50-year-olds
Vaccination deep into a pandemic wave potential mechanisms for a "third wave" and the impact of vaccination
Vaccination deep into a pandemic wave potential mechanisms for a "third wave" and the impact of vaccination
Economics of employer-sponsored workplace vaccination to prevent pandemic and seasonal influenza
Economics of employer-sponsored workplace vaccination to prevent pandemic and seasonal influenza
Ambulatory antibiotic use and prescription drug coverage in older adults
Ambulatory antibiotic use and prescription drug coverage in older adults
The potential value of Clostridium difficile vaccine: An economic computer simulation model
The potential value of Clostridium difficile vaccine: An economic computer simulation model
Single versus multi-dose vaccine vials: An economic computational model
Single versus multi-dose vaccine vials: An economic computational model
Seroprevalence following the second wave of pandemic 2009 H1N1 influenza in Pittsburgh, PA, USA
Seroprevalence following the second wave of pandemic 2009 H1N1 influenza in Pittsburgh, PA, USA
Screening of cardiac surgery patients for MRSA: an economic computer model
Screening of cardiac surgery patients for MRSA: an economic computer model
A computer simulation of vaccine prioritization, allocation, and rationing during the 2009 H1N1 influenza pandemic
A computer simulation of vaccine prioritization, allocation, and rationing during the 2009 H1N1 influenza pandemic
To test or to treat? An analysis of influenza testing and antiviral treatment strategies using economic computer modeling
To test or to treat? An analysis of influenza testing and antiviral treatment strategies using economic computer modeling
The potential economic value of a Staphylococcus aureus vaccine for neonates
The potential economic value of a Staphylococcus aureus vaccine for neonates
Simulating school closure strategies to mitigate an influenza epidemic
Simulating school closure strategies to mitigate an influenza epidemic
Staphylococcus aureus vaccine for orthopedic patients: An economic model and analysis
Staphylococcus aureus vaccine for orthopedic patients: An economic model and analysis