Research
For over two decades, Bruce and his team have been developing and utilizing computer, AI, and systems approaches, methods, models, and tools to help decision makers better understand and address complex systems in health and public health. This has included the research efforts described below and other initiatives described here.
Bruce has been the Principal Investigator for over $60 million in grants/contracts from a variety of organizations and agencies including the National Institutes of Health (NIH), the Agency for Healthcare Quality and Research (AHRQ), the National Science Foundation (NSF), the Centers for Disease Control and Prevention (CDC), UNICEF, the Global Fund, the Bill & Melinda Gates Foundation, and the U.S. Agency for International Development (USAID).
Bruce and his PHICOR team have published over 295 publications in scientific peer-reviewed journals (e.g., The Lancet, Health Affairs, The New England Journal of Medicine, American Journal of Public Health, American Journal of Preventive Medicine) with Dr. Lee being first author for over 110 and last author for over 120 of them, most of which have been original research. Much of this research has involved working directly with a range of different local, state, national, and international decision-makers.
To find or sort these different scientific publications by topic, use the filtering option below and to the left.
The value of decreasing the duration of the infectious period of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
The value of decreasing the duration of the infectious period of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
PLos Computational Biology
The benefits of vaccinating with the first available COVID-19 coronavirus vaccine
The benefits of vaccinating with the first available COVID-19 coronavirus vaccine
American Journal of Preventive Medicine
Lives and Costs Saved by Expanding and Expediting Coronavirus Disease 2019 Vaccination
Lives and costs saved by expanding and expediting coronavirus disease 2019 vaccination
Journal of Infectious Disease
Maintaining face mask use before and after achieving different COVID-19 vaccination coverage levels: a modelling study
Maintaining face mask use before and after achieving different COVID-19 vaccination coverage levels: a modelling study
Lancet Public Health
The potential clinical and economic value of a human papillomavirus primary screening test that additionally identifies genotypes 31, 45, 51, and 52 individually
The potential clinical and economic value of a human papillomavirus primary screening test that additionally identifies genotypes 31, 45, 51, and 52 individually
Sexually Transmitted Diseases
How long-term acute care hospitals (LTACHs) can play an important role in controlling carbapenem-resistant enterobacteriaceae (CRE) in a region: A simulation modeling study
How long-term acute care hospitals (LTACHs) can play an important role in controlling carbapenem-resistant enterobacteriaceae (CRE) in a region: A simulation modeling study
American Journal of Epidemiology
How to choose target facilities in a region to implement carbapenem-resistant Enterobacteriaceae (CRE) control measures
How to choose target facilities in a region to implement carbapenem-resistant Enterobacteriaceae (CRE) control measures
Clinical Infectious Disease
Potential clinical and economic value of norovirus vaccination in the community setting
Potential clinical and economic value of norovirus vaccination in the community setting
American Journal of Preventive Medicine
Estimated number of N95 respirators needed for healthcare workers in acute-care hospitals during the coronavirus disease 2019 (COVID-19) pandemic
Estimated number of N95 respirators needed for healthcare workers in acute-care hospitals during the coronavirus disease 2019 (COVID-19) pandemic
Infection Control and Hospital Epidemiology
The clinical and economic burden of norovirus gastroenteritis in the United States
The clinical and economic burden of norovirus gastroenteritis in the United States
Journal of Infectious Disease
Replacing the measles multi-dose vaccine presentation with the single-dose presentation in Thailand
Replacing the measles multi-dose vaccine presentation with the single-dose presentation in Thailand
Vaccine
Economic value of Acinetobacter baumannii screening in the intensive care unit (ICU)
Economic value of Acinetobacter baumannii screening in the intensive care unit (ICU)
Clinical Microbiology Infection
Economic value of dengue vaccine in Thailand
Economic value of dengue vaccine in Thailand
The American Journal of Tropical Medicine and Hygiene
What if the influenza vaccine did not offer such variable protection?
What if the influenza vaccine did not offer such variable protection?
Vaccine efficacy needed for a COVID-19 coronavirus vaccine to prevent or stop an epidemic as the sole intervention
Vaccine efficacy needed for a COVID-19 coronavirus vaccine to prevent or stop an epidemic as the sole intervention
AJPM’s Paper of the Year 2020
Knowing more of the iceberg: How detecting a greater proportion of carbapenem-resistant Enterobacteriaceae (CRE) carriers impacts transmission
Knowing more of the iceberg: How detecting a greater proportion of carbapenem-resistant Enterobacteriaceae (CRE) carriers impacts transmission
The Journal of Infectious Diseases
The benefits to all of ensuring equal and timely access to influenza vaccines in poor communities
The benefits to all of ensuring equal and timely access to influenza vaccines in poor communities
Health Affairs
Would school closure for the 2009 H1N1 influenza epidemic have been worth the cost
Would school closure for the 2009 H1N1 influenza epidemic have been worth the cost
BMC Public Health
The potential healthcare cost and resource use associated with COVID-19 coronavirus in the United States
The potential healthcare cost and resource use associated with COVID-19 coronavirus in the United States
Health Affairs
The potential economic value of a therapeutic chagas disease vaccine for pregnant women to prevent congenital transmission
The potential economic value of a therapeutic chagas disease vaccine for pregnant women to prevent congenital transmission
Vaccine
Vaccine eligibility and acceptance among ambulatory obstetric and gynecologic patients
Vaccine eligibility and acceptance among ambulatory obstetric and gynecologic patients
Vaccine
How introducing a registry with automated alerts for carbapenem-resistant Enterobacteriaceae (CRE) may help control CRE spread in a region
How introducing a registry with automated alerts for carbapenem-resistant Enterobacteriaceae (CRE) may help control CRE spread in a region
Clinical Infectious Diseases
The potential economic value of a Zika vaccine for a woman of childbearing age
The potential economic value of a Zika vaccine for a woman of childbearing age
American Journal of Preventive Medicine
The economic value of screening hemodialysis patients for methicillin-resistant Staphylococcus aureus (MRSA) in the United States
The economic value of screening hemodialysis patients for methicillin-resistant Staphylococcus aureus (MRSA) in the United States
Clinical Microbiology and Infection
The role of subway travel in an influenza epidemic: a New York City simulation
The role of subway travel in an influenza epidemic: a New York City simulation
Journal of Urban Health
Alternative vaccination locations: Who uses them and can they increase flu vaccination rates
Alternative vaccination locations: Who uses them and can they increase flu vaccination rates
Vaccine
Economic value of a therapeutic Chagas vaccine for inderterminate and chagasic cardiomyopathy patients
Economic value of a therapeutic Chagas vaccine for inderterminate and chagasic cardiomyopathy patients
Vaccine
Epidemiologic and economic impact of methicillin-resistant Staphylococcus aureus in obstetrics
Epidemiologic and economic impact of methicillin-resistant Staphylococcus aureus in obstetrics
Obstetrics and Gynecology
Economic value of vaccinating geographically hard-to-reach populations with measles vaccine: Modeling application in Kenya
Economic value of vaccinating geographically hard-to-reach populations with measles vaccine: Modeling application in Kenya
Vaccine
A predictive model of the economic effects of an influenza vaccine adjuvant for the older adult (age 65 and over) population
A predictive model of the economic effects of an influenza vaccine adjuvant for the older adult (age 65 and over) population
Vaccine
Tracking the spread of carbapenem-resistant enterobacteriaceae (CRE) through clinical cultures alone underestimates the spread of CRE even more than anticipated
Tracking the spread of carbapenem-resistant enterobacteriaceae (CRE) through clinical cultures alone underestimates the spread of CRE even more than anticipated
Infection Control and Hospital Epidemiology
The SHIELD Orange County project -multi drug- resistant organism (MDRO) prevalence in 21 nursing homes and long term acute care facilities in southern California
The SHIELD Orange County project -multi drug- resistant organism (MDRO) prevalence in 21 nursing homes and long term acute care facilities in southern California
Clinical Infectious Diseases
The potential effects of introducing microneedle patch vaccines into routine vaccine supply chain
The potential effects of introducing microneedle patch vaccines into routine vaccine supply chain
Vaccine
What is the value of different Zika vaccination strategies to prevent and mitigate Zika outbreaks?
What is the value of different Zika vaccination strategies to prevent and mitigate Zika outbreaks?
The Journal of Infectious Diseases
Epidemiologic and economic impact of pharmacies as vaccination locations during an influenza epidemic
Epidemiologic and economic impact of pharmacies as vaccination locations during an influenza epidemic
Vaccine
The economic value of identifying and treating Chagas disease patients earlier and the impact on Trypanosoma cruzi transmission
The economic value of identifying and treating Chagas disease patients earlier and the impact on Trypanosoma cruzi transmission
PLoS Neglected Tropical Diseases
The impact of healthcare-associated methicillin-resistant Staphylococcus aureus infections on post-discharge costs and utilization
The impact of healthcare-associated methicillin-resistant Staphylococcus aureus infections on post-discharge costs and utilization
Infection Control & Hospital Epidemiology
Complementary paths to Chagas disease elimination: The impact of combining vector control with aetiological treatment
Complementary paths to Chagas disease elimination: The impact of combining vector control with aetiological treatment
Estimated cost to a restaurant of a foodborne illness outbreak
Estimated cost to a restaurant of a foodborne illness outbreak
Virtual epidemic in a virtual city: Simulating the spread of influenza in a United States metropolitan area
Virtual epidemic in a virtual city: Simulating the spread of influenza in a United States metropolitan area
The economic value of the Centers for Disease Control and Prevention (CDC) Carbapenem-Resistant Enterobacteriaceae (CRE) toolkit
The economic value of the Centers for Disease Control and Prevention (CDC) Carbapenem-Resistant Enterobacteriaceae (CRE) toolkit
Are the London Declaration’s 2020 goals sufficient to control Chagas disease? Modeling scenarios for the Yucantan Peninsula
Are the London Declaration’s 2020 goals sufficient to control Chagas disease? Modeling scenarios for the Yucantan Peninsula
The economic value of long-lasting insecticidal Nets (LLINs) and indoor residual spraying (IRS) implementation in Mozambique
The economic value of long-lasting insecticidal Nets (LLINs) and indoor residual spraying (IRS) implementation in Mozambique
How to determine if a model is right for neglected tropical disease decision making
How to determine if a model is right for neglected tropical disease decision making
Geospatial planning and the resulting economic impact of human Papillomavirus (HPV) vaccine introduction in Mozambique
Geospatial planning and the resulting economic impact of human Papillomavirus (HPV) vaccine introduction in Mozambique
From the patient perspective: the economic value of seasonal and H1N1 influenza vaccination
From the patient perspective: the economic value of seasonal and H1N1 influenza vaccination
Comparison and validation of two computational models of Chagas disease: a thirty year perspective from Venezuela
Comparison and validation of two computational models of Chagas disease: a thirty year perspective from Venezuela
Impact of delays between the Clinical and Laboratory Standards Institute (CLSI) and the Food and Drug Administration (FDA)
Impact of delays between the Clinical and Laboratory Standards Institute (CLSI) and the Food and Drug Administration (FDA) revising interpretive criteria for Carbapenem-Resistant Enterobacteriaceae (CRE)
Potential economic burden of carbapenem-resistant Enterobacteriaceae (CRE) in the United States
Potential economic burden of carbapenem-resistant Enterobacteriaceae (CRE) in the United States
The global economic and health burden of human hookworm infection
The global economic and health burden of human hookworm infection